Why the study?
Do the ubiquitin ligases MuRF1 and MAFbx mediate skeletal muscle atrophy?
Population
Rat models of atrophy, myotubes, and mice deficient in MAFbx or MuRF1
Comparison
Overexpression of MAFbx in myotubes; genetic… vs Wild-type or control models
Design
Preclinical
Authors
Loading...
Animal data link MAFbx/MuRF1 to atrophy; leaves open their therapeutic targeting in human muscle wasting.
Do the ubiquitin ligases MuRF1 and MAFbx mediate skeletal muscle atrophy?
MuRF1 and MAFbx are critical ubiquitin ligases required for skeletal muscle atrophy, identifying them as potential therapeutic targets.
Bodine et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: