Why the study?
Do the ubiquitin ligases MuRF1 and MAFbx mediate skeletal muscle atrophy?
Do the ubiquitin ligases MuRF1 and MAFbx mediate skeletal muscle atrophy?
MuRF1 and MAFbx are critical ubiquitin ligases required for skeletal muscle atrophy, identifying them as potential therapeutic targets.
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Animal data link MAFbx/MuRF1 to atrophy; leaves open their therapeutic targeting in human muscle wasting.
Bodine et al. (2001) studied this question.
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