What question did this study set out to answer?

To evaluate the persistence of IgG and IgM anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and assess their value as thrombotic risk markers in patients with suspected antiphospholipid syndrome.

October 21, 2021Frontiers in ImmunologyOpen Access

Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk

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Authors

NENatalia EgriHospital Clínic de Barcelona CBChelsea BentowAutoimmune Technologies (United States)LRLaura RubióUniversitat de Lleida

Discussion

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Implication

Cohort study reveals persistent anti-phosphatidylserine/prothrombin IgG antibodies associate with thrombosis in suspected APS, indicating their utility in thrombotic risk assessment.

Key Points

To evaluate the persistence of IgG and IgM anti-phosphatidylserine/prothrombin (aPS/PT) antibodies and assess their value as thrombotic risk markers in patients with suspected antiphospholipid syndrome.
Assessed a consecutive cohort of patients with clinical suspicion of antiphospholipid syndrome (N=103).
Measured aPS/PT IgG and IgM antibodies at two distinct time points alongside standard antiphospholipid syndrome classification markers (lupus anticoagulant, anticardiolipin, and anti-beta-2 glycoprotein I).
Persistently positive aPS/PT IgG antibodies significantly associated with antiphospholipid syndrome classification, thrombosis, triple aPL positivity, lupus anticoagulant positivity, and a Global APS Score greater than 9 (p < 0.01 for each).
No significant association was observed between persistent aPS/PT antibodies and pregnancy morbidity (p = 0.56) or systemic lupus erythematosus (p = 0.07).

Cite This Study

Egri et al. (2021) studied this question.

synapsesocial.com/papers/69d764e8f182769aa8b8afb8 https://doi.org/10.3389/fimmu.2021.754469

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Implication

Cohort study reveals persistent anti-phosphatidylserine/prothrombin IgG antibodies associate with thrombosis in suspected APS, indicating their utility in thrombotic risk assessment.

Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk

Discussion

Member takes

Implication

Key Points

Cite This Study

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