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September 10, 2025Frontiers in ImmunologyOpen Access

Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome

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Authors

ÓCÓscar Cabrera-MaranteDPDaniel E. PleguezueloSGSara Garcinuño

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Overview

Analysis reveals differing impacts of criteria and non-criteria antibodies on thrombosis in antiphospholipid syndrome, highlighting important clinical implications.

Key Points

  • Classic and extra-criteria antibodies show significant associations with thrombotic events in patients with antiphospholipid syndrome.
  • IgA anti-beta 2 glycoprotein I was notably associated with various types of thrombosis, including pulmonary embolism and stroke.
  • Classic anti-phospholipid antibodies of IgM isotype were highly correlated with obstetric complications like gestational morbidity.
  • The presence of aPS/PT antibodies suggests they should be considered alongside lupus anticoagulant, rather than as a surrogate marker.

Cite This Study

Cabrera-Marante et al. (2025) studied this question.

synapsesocial.com/papers/68c1a5ff54b1d3bfb60e013ehttps://doi.org/10.3389/fimmu.2025.1636171
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Noncriteria antiphospholipid antibodies in antiphospholipid syndrome2024 · 8 citations
  2. 2Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk2021 · 31 citations
  3. 3Clinical relevance of antiphosphatidylserine/prothrombin antibodies in antiphospholipid syndrome2026
  4. 4Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damage2026 · 1 citations
  5. 5IgM antiphospholipid antibodies are associated with a microvascular phenotype in antiphospholipid syndrome2026