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June 13, 2026Advances in RheumatologyOpen Access

IgM antiphospholipid antibodies are associated with a microvascular phenotype in antiphospholipid syndrome

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Authors

FSFlávio SignorelliFLFernanda Oliveira de Andrade LopesAGAndreia Coimbra Sousa Gomes

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Overview

Retrospective multicenter study evaluates IgM antibodies' impact on clinical features in APS, suggesting unique microvascular involvement.

Key Points

  • This study aims to evaluate the impact of IgM antiphospholipid antibodies on the clinical phenotype of primary antiphospholipid syndrome.
  • Retrospective multicenter study
  • Patients categorized into isolated-LA, isolated-IgM-aPL, and LA + IgM-aPL profiles
  • Clinical features compared between groups
  • In 202 patients, 8.4% had isolated-IgM-aPL and showed lower female prevalence (41.2% vs. 65.5%; p=0.049)
  • Isolated-IgM-aPL had fewer venous thromboses (41.2% vs. 66%; p=0.049) but more obstetric morbidity (58.8% vs. 26.2%; p=0.005)
  • Higher proportions of livedo racemosa (47.1% vs. 20.7%; p=0.015) and white matter lesions (WML) (29.4% vs. 9.7%; p=0.020) in isolated-IgM-aPL group

Cite This Study

Signorelli et al. (2026) studied this question.

synapsesocial.com/papers/6a2cf701faef96ed7f058a3fhttps://doi.org/10.1186/s42358-026-00553-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IgM Antiphospholipid Antibodies in Antiphospholipid Syndrome: Prevalence, Clinical Associations, and Diagnostic Implications—A Scoping Review2025 · 2 citations
  2. 2Patterns of antiphospholipid antibody positivity in a real-world laboratory over two decades2025
  3. 3Criteria and non-criteria anti-phospholipid antibodies in the different clinical forms of antiphospholipid syndrome2025 · 5 citations
  4. 4Antiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damage2026 · 1 citations
  5. 5Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk2021 · 31 citations