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December 8, 2025Blood

Patterns of antiphospholipid antibody positivity in a real-world laboratory over two decades

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Authors

RAReema Abdulrahman S. Alyamani

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Overview

Analysis of antiphospholipid antibody testing reveals isolated IgM positivity affects diagnosis in patients with antiphospholipid syndrome.

Key Points

  • This analysis aims to evaluate the prevalence of isolated IgM positivity in antiphospholipid antibody testing.
  • Analyzed antiphospholipid antibody testing data from Mayo Clinic sites from 2006-2025.
  • Identified a cohort of patients who underwent simultaneous testing for various aPL markers.
  • Calculated positivity rates for Lupus anticoagulant, anticardiolipin, and anti–beta 2 glycoprotein isotypes.
  • 99,814 unique patients were tested for at least one aPL marker.
  • Positivity rate for Lupus anticoagulant was 10.29%.
  • 2.2% of the cohort tested positive for only IgM isotypes (either anticardiolipin or beta 2 glycoprotein).

Cite This Study

Reema Abdulrahman S. Alyamani (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d645https://doi.org/10.1182/blood-2025-1331
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Also Consider

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  1. 1IgM antiphospholipid antibodies are associated with a microvascular phenotype in antiphospholipid syndrome2026
  2. 2IgM Antiphospholipid Antibodies in Antiphospholipid Syndrome: Prevalence, Clinical Associations, and Diagnostic Implications—A Scoping Review2025 · 2 citations
  3. 3Laboratory assessment of antiphospholipid syndrome: Laboratory data2024 · 1 citations
  4. 4Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)2026
  5. 5Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk2021 · 31 citations