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September 5, 2026Lupus

Clinical characteristics of patients with primary antiphospholipid syndrome and “single” antiphospholipid antibody: Retrospective results from the APS ACTION clinical database and repository (“registry”)

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Authors

SFSilvia Grazietta FoddaiICIrene CecchiMRMassimo Radin

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Overview

Retrospective registry study reveals lupus anticoagulant dominance and recurrent clotting in primary antiphospholipid syndrome, highlighting the need for tailored risk stratification.

Key Points

  • To evaluate the prevalence, clinical characteristics, and cardiovascular disease risk profile of persistently single antiphospholipid antibody-positive patients with primary antiphospholipid syndrome.
  • Conducted a retrospective cohort study using data from the international APS ACTION registry.
  • Evaluated 233 primary antiphospholipid syndrome (PAPS) patients and 97 antiphospholipid antibody (aPL)-positive controls without an APS classification tested for lupus anticoagulant (LA), anticardiolipin (aCL), and anti-β2-glycoprotein I (aβ2GPI).
  • Single aPL positivity was present in 36% (84/233) of PAPS patients, consisting of 79% (67/84) with LA, 10% (8/84) with aCL, and 11% (9/84) with aβ2GPI.
  • Historical thrombosis recurrence occurred in 26% of single aPL-positive PAPS patients, with 86% of recurrent events occurring in patients with isolated LA positivity.
  • Single LA positivity was significantly more frequent in PAPS patients, whereas isolated aCL IgM and aβ2GPI IgM were significantly more common in non-APS controls (22.7% total single aPL positivity, 22/97).

Cite This Study

Foddai et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4346b95aff0620eb9dbhttps://doi.org/10.1177/09612033261479899
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of clinical and serological features in thrombotic antiphospholipid syndrome patients, with and without associated systemic lupus erythematosus, followed for up to 42 years: A single centre retrospective study2024 · 5 citations
  2. 2Patterns of antiphospholipid antibody positivity in a real-world laboratory over two decades2025
  3. 3Anti-Phosphatidylserine/Prothrombin Antibodies at Two Points: Correlation With Lupus Anticoagulant and Thrombotic Risk2021 · 31 citations
  4. 4IgM antiphospholipid antibodies are associated with a microvascular phenotype in antiphospholipid syndrome2026
  5. 5Thrombotic antiphospholipid syndrome: Recurrent thromboses2024 · 2 citations