Extra criterial antiphospholipid antibodies in patients with antiphospholipid syndrome and systemic lupus erythematosus (preliminary data)

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The role of antiphospholipid antibodies (aPL), which are not included in the classification criteria, in antiphospholipid syndrome (APS) andsystemic lupus erythematosus (SLE) is not well understood.Objective: to determine the frequency of detection of IgG antibodies to domain 1 of β 2 -glycoprotein 1 (IgG-aβ 2 GP 1 -D 1 ), IgA antibodiesto cardiolipin (aCL) and IgA antibodies to β 2 -glycoprotein 1 (IgA-a β 2 GP 1 ) in patients with primary APS and APS in combination withSLE. Patients and methods . The study included 63 patients in whom IgG/IgM-aCL and IgG/IgM-aβ 2 GP 1 were detected by enzyme-linkedimmunosorbent assay (ELISA) and IgG/IgM/IgA-aCL, IgG/IgM/IgA-aβ 2 GP 1 and IgG-aβ 2 GP 1 -D 1 by chemiluminescence analysis (CLA). Results and discussion . The detection rate of IgG-aβ 2 GP 1 -D 1 was 76%, IgA-aCL – 56%, IgA-aβ 2 GP 1 – 48%. Isolated positivity for IgA-aCL,IgA-aβ 2 GP 1 , IgG-aβ 2 GP 1 -D1 was not observed. The presence of IgA-aCL, IgA-aβ 2 GP 1 , IgG-aβ 2 GP 1 -D 1 was associated with high positivity forIgG/IgM-aCL and IgG/IgM-aβ 2 GP 1 . There was a statistically significant relationship between IgA-aCL/IgA-aβ 2 GP 1 and the standard aPLprofile, as well as IgG-aβ 2 GP 1 -D 1 , IgG-aCL and IgG-aβ 2 GP 1 . Conclusion . A high detection rate of IgG-aβ2GP 1 -D 1 , IgA-aCL, IgA-aβ 2 GP 1 was found in patients with APS. A statistically significant relationshipwas found between IgA-aCL/IgA-aβ 2 GP 1 and the standard aPL profile, as well as IgG-aβ 2 GP 1 -D 1 with IgG-aCL and IgG-aβ 2 GP 1 .