What question did this study set out to answer?

Update and expand the CellMarker database to provide a comprehensive, manually curated resource of cell-type markers and analytical tools for single-cell RNA sequencing data in humans and mice.

October 27, 2022Nucleic Acids ResearchOpen Access

CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data

View Full Paper

Ask AI

Bookmark

Authors

CHCongxue HuHarbin Medical University TLTengyue LiHarbin Medical University YXYingqi XuHarbin Medical University

Discussion

Member takes

Implication

Database update reveals an expanded repository of curated human and mouse cell markers, facilitating single-cell RNA sequencing analysis and cell annotation.

Key Points

Update and expand the CellMarker database to provide a comprehensive, manually curated resource of cell-type markers and analytical tools for single-cell RNA sequencing data in humans and mice.
Curated experimentally supported cell markers across human and mouse tissues derived from literature and 48 single-cell sequencing platforms, such as 10X Chromium, Smart-Seq2, and Drop-seq.
Expanded biological scope by incorporating 29 marker classes, including protein-coding genes, long non-coding RNAs, and processed pseudogenes.
Engineered six web tools for single-cell data analysis covering cell annotation, clustering, malignancy, differentiation, cell features, and intercellular communication.
Added 36,300 entries, 474 tissues, 1,901 cell types, and 4,566 markers, bringing the current total to 83,361 tissue-cell type-marker entries, 26,915 cell markers, 2,578 cell types, and 656 tissues.
Integrated single-cell sequencing technology sources across 48 distinct platforms.
Delivered six functional web-based applications to analyze and visualize single-cell sequencing datasets directly within the platform.

Cite This Study

Hu et al. (2022) studied this question.

synapsesocial.com/papers/69d77df6db9d5e1bf4b8b1c2 https://doi.org/10.1093/nar/gkac947

View Full Paper

Ask AI

Bookmark

Implication

Database update reveals an expanded repository of curated human and mouse cell markers, facilitating single-cell RNA sequencing analysis and cell annotation.

CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data

Discussion

Member takes

Implication

Key Points

Cite This Study

CellMarker 2.0: an updated database of manually curated cell markers in human/mouse and web tools based on scRNA-seq data

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider