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This research aims to explore how exogenous acetate contributes to butyrate formation by human faecal bacteria.

Contribution of acetate to butyrate formation by human faecal bacteria

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This research aims to explore how exogenous acetate contributes to butyrate formation by human faecal bacteria.
Used 60 mm-acetate and 10 mm-glucose to study butyrate production from acetate by specific bacterial strains.
Investigated butyrate formation across different carbohydrate-derived energy sources in continuous and batch cultures.
Faecalibacterium prausnitzii and Roseburia spp. derived 85-90% butyrate-C from external acetate, while a Coprococcus-related strain derived only 28%.
In continuous cultures, external acetate contribution to butyrate formation ranged from 56-90%, varying with the substrate used.
Batch cultures showed a contribution range of 72-91% from external acetate.

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Randomized trial investigates how acetate affects butyrate production in human gut bacteria, suggesting dietary implications.

Duncan et al. (2004) studied this question.

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