What question did this study set out to answer?

To determine whether colonic fermentation of unabsorbed dietary carbohydrates alters systemic concentrations and kinetics of short-chain fatty acids in circulating blood.

May 1, 1985Journal of Clinical InvestigationOpen Access

Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood.

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To determine whether colonic fermentation of unabsorbed dietary carbohydrates alters systemic concentrations and kinetics of short-chain fatty acids in circulating blood.
Measured fasting (16-hour) venous and arterial blood short-chain fatty acid concentrations in healthy human subjects (N=14 fasting; N=6 simultaneous arterial and venous).
Assessed postprandial venous blood acetate kinetics following oral administration of 50 mmol mixed short-chain fatty acids, lactulose (5, 10, or 20 g), or pectin (20 g).
Fasting venous acetate was 53.8 ± 4.4 µmol/L (n=14) and arterial acetate was 125.6 ± 13.5 µmol/L (vs. venous 61.1 ± 6.9 µmol/L; n=6), while propionate and butyrate were undetectable.
Venous blood acetate peaked at 45 minutes following oral short-chain fatty acids (194.1 ± 57.9 µmol/L) and showed dose-dependent peaks at 2–4 hours with lactulose (5 g: 98.6 ± 23.1; 10 g: 127.3 ± 18.2; 20 g: 181.3 ± 23.9 µmol/L).
Pectin fermentation initiated acetate elevation after 6 hours and persisted for 18 hours, with total blood acetate area under the curve strongly correlating across acetate sources (r = 0.97; n=5).

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Implication

Interventional study demonstrates colonic carbohydrate fermentation substantially elevates systemic blood acetate in healthy humans, indicating fermentation impacts metabolism beyond the gut.

Cite This Study

Pomare et al. (1985) studied this question.

synapsesocial.com/papers/6a1d8be75b7fddc352056cc1 https://doi.org/10.1172/jci111847

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Implication

Interventional study demonstrates colonic carbohydrate fermentation substantially elevates systemic blood acetate in healthy humans, indicating fermentation impacts metabolism beyond the gut.

Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood.

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Discussion

Implication

Cite This Study

Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood.

Key Points

Discussion

Implication

Cite This Study

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