Young patients with HFpEF experience significant adverse cardiac remodeling and poor outcomes, with obesity identified as a potential major driver.
Alerts clinicians to poor outcomes in young HFpEF; leaves open whether obesity-targeted strategies improve remodeling and prognosis.
Young and very young patients with HFpEF display similar adverse cardiac remodeling compared with their older counterparts and very poor outcomes compared with control subjects without heart failure. Obesity may be a major driver of HFpEF in a high proportion of HFpEF in the young and very young.
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Tromp et al. (2018) studied this question.
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