Why the study?
Does ablation therapy combined with antiarrhythmic drug therapy prevent atrial arrhythmia recurrences in patients with drug-refractory paroxysmal or persistent atrial fibrillation?
Does ablation therapy combined with antiarrhythmic drug therapy prevent atrial arrhythmia recurrences in patients with drug-refractory paroxysmal or persistent atrial fibrillation?
In patients with drug-refractory paroxysmal or persistent atrial fibrillation, catheter ablation combined with antiarrhythmic drugs is superior to drugs alone for preventing arrhythmia recurrence.
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Supports combined ablation-AAD strategy in refractory AF; extends RCT evidence beyond drug monotherapy.
Stabile et al. (2005) studied this question.
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