Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation

Ester Ciociola; Tanmoy Dutta; Kavitha Sasidharan; Lohitesh Kovooru; Francesca Rita Noto; Grazia Pennisi; Salvatore Petta; Angela Mirarchi; Samantha Maurotti; Bernardette Scopacasa; Luca Tirinato; Patrizio Candeloro; Marcus Henricsson; Daniel Lindén; Oveis Jamialahmadi; Arturo Pujia; Rosellina Margherita Mancina; Stefano Romeo

doi:10.3350/cmh.2024.0642

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Abstract

MARC1 downregulation in carriers of the risk allele results in lower hepatocyte neutral lipids content due to higher β-oxidation, while upregulating beneficial pathways involved in cell survival.

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Ciociola et al. (2024) studied this question.

synapsesocial.com/papers/69d7b9e96a6ff5a83cbed845 https://doi.org/10.3350/cmh.2024.0642

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Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation

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Abstract

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Downregulation of the MARC1 p.A165 risk allele reduces hepatocyte lipid content by increasing beta-oxidation

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Abstract

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