Why the study?
What are the pharmacokinetic and pharmacodynamic differences between the R and S enantiomers of warfarin in humans?
What are the pharmacokinetic and pharmacodynamic differences between the R and S enantiomers of warfarin in humans?
S warfarin is a more potent anticoagulant than R warfarin in humans, despite having a shorter plasma half-life.
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Enantiomer potency differences warrant targeted research; should not yet alter clinical warfarin dosing or monitoring.
Breckenridge et al. (1974) studied this question.