Key result
Inflammation impairs reverse cholesterol transport independent of HDL-C, driven by reduced hepatobiliary flux.
Why the study?
Inflammation may impair reverse cholesterol transport (RCT) at multiple steps, potentially contributing to atherosclerosis in chronic inflammatory states.
Does inflammation impair reverse cholesterol transport in vivo?
Does inflammation impair reverse cholesterol transport in vivo?
This study provides the first in vivo evidence that inflammation impairs reverse cholesterol transport, suggesting a mechanism for atherosclerosis in chronic inflammatory states independent of HDL levels.
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Inflammation may impair RCT independent of HDL-C; extends mechanistic understanding of atherosclerosis in chronic inflammatory states.
McGillicuddy et al. (2009) studied this question. Inflammation impairs reverse cholesterol transport at multiple steps, particularly cholesterol flux through the liver to bile and feces, independent of HDL cholesterol levels.
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