Are obesity and diabetes additively associated with adverse cardiovascular biomarkers and mortality risk in the UK Biobank cohort?
Obesity and diabetes have an additive association with cardiovascular risk, but the weak correlation of their metrics with biomarkers suggests other factors drive risk in normal-weight diabetes.
Obesity and diabetes are additively associated with adverse cardiovascular biomarkers and mortality risk. While adiposity metrics are more strongly correlated with cardiovascular biomarkers than diabetes-oriented metrics, both correlate weakly, suggesting that other factors underpin the high cardiovascular risk of normal-weight diabetes.
Brown et al. (Tue,) studied this question.