Why the study?
Calcification and bicuspid valve formation disturb hemodynamics and valve function, and detailed analysis of aortic valve hemodynamics would lead to a better understanding of disease etiology.
Computational modeling demonstrates that calcification and bicuspid valve morphology significantly alter aortic valve hemodynamics, creating complex wall shear stress patterns on the fibrosa side that may promote further disease progression.
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Calcification-driven shear stresses may accelerate valve disease; leaves open mechanistic role and human translation from animal models.
Salman et al. (2021) studied this question.
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