What question did this study set out to answer?

To investigate the involvement of adaptive and innate immune responses, specifically the Th17 pathway, in early clinically visible inflamed acne lesions compared to healthy skin.

August 25, 2014SHILAP Revista de lepidopterologíaOpen Access

IL-17/Th17 Pathway Is Activated in Acne Lesions

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Authors

HKHanna‐Leena KelhäläOulu University Hospital RPRiitta PalatsiUniversity of Helsinki NFNanna FyhrquistKarolinska Institutet

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Implication

Comparative tissue analysis reveals activation of the interleukin-17 pathway and immune cell infiltration in acne lesions, suggesting new targets for anti-inflammatory therapy.

Key Points

To investigate the involvement of adaptive and innate immune responses, specifically the Th17 pathway, in early clinically visible inflamed acne lesions compared to healthy skin.
Obtained paired lesional and non-lesional skin biopsies from two independent cohorts of acne patients.
Profiled gene and protein expression using Affymetrix GeneChips, real-time PCR, and Luminex multiplex assays.
Evaluated immune cell infiltration in skin tissue via immunohistochemical staining for IL-17A-positive T cells and CD83-positive dendritic cells.
Signature Th17 cytokines, particularly IL-17 at both the RNA and protein level, were significantly elevated in acne lesions compared to non-lesional skin.
Upstream cytokines promoting Th17 differentiation (IL-1b, IL-6, TGF-b, IL-23p19), Th1 markers, regulatory T cell markers, and antimicrobial peptides (S100A7, S100A9, hBD2, hBD3) were markedly induced.
Immunohistochemistry demonstrated significantly increased infiltration of IL-17A-positive T cells and CD83 dendritic cells within inflamed acne lesions.

Cite This Study

Kelhälä et al. (2014) studied this question.

synapsesocial.com/papers/69d7d33ef39344339dd1889c https://doi.org/10.1371/journal.pone.0105238

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Implication

Comparative tissue analysis reveals activation of the interleukin-17 pathway and immune cell infiltration in acne lesions, suggesting new targets for anti-inflammatory therapy.

IL-17/Th17 Pathway Is Activated in Acne Lesions

Discussion

Member takes

Implication

Key Points

Cite This Study

IL-17/Th17 Pathway Is Activated in Acne Lesions

Discussion

Member takes

Implication

Key Points

Cite This Study

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