The Evaluation of IL-17A and IL17 F Level in Patient Suffer from Acne Vulgaris and their association with the severity : cytokines implicated in Acne Vulgaris

Background: Acne vulgaris is very common, long-lasting, inflammatory skin condition that mostly affects the pilosebaceous area on the face, neck, upper trunk, and back .It is a widespread, multifactorial skin condition that affects people all over the world. The pilosebaceous follicle of acne vulgaris causes together non-inflammatory and inflammatory lesions. The natural cycling of sebaceous follicles can be disrupted by environmental and genetic variables, which may lead the improvement of inflammatory injuries and comedones. The improvement of spots injuries is significantly influenced by genetic factors and pro-inflammatory cytokines Aim: The aim of this study is to evaluate IL-17A and IL17 F level in adult through acne vulgaris and their relationship with the acne strictness. Methods: This study included 60 patients with Acne vulgaris who were admitted to hospital from the period November /2022 – march/ 2023 and other group consist of 60 apparently healthy individuals used as a control. Immunological study conducted to evaluate serum IL17A,IL17F using Sandwich Eliza technique. Results: Both Il17A and IL17 F was significantly higher in patient with acne vulgaris. Conclusion: Both IL17A and IL17F, can be used as predictive and diagnostic biomarkers for Acne vulgaris.