Effect of Discontinuation of Antihypertensive Treatment in Elderly People on Cognitive Functioning—the DANTE Study Leiden

Key Points

• To evaluate the effect of discontinuing antihypertensive medication on cognitive functioning in older individuals.
• Randomized clinical trial protocol registered under trialregister.nl Identifier NTR2829 (DANTE Study Leiden).
• Intervention involves stopping antihypertensive treatment compared to continuing standard therapy in an older adult population.
• The trial evaluates changes in overall cognitive performance and domain-specific executive function following treatment cessation.
• Outcomes determine whether deprescribing antihypertensive medications improves or impairs cerebral perfusion and cognitive status.