Why the study?
Does treatment with a thiazide diuretic or atenolol adversely affect cognitive function in older adults with mild hypertension?
Does treatment with a thiazide diuretic or atenolol adversely affect cognitive function in older adults with mild hypertension?
Short-term treatment of mild hypertension with a thiazide diuretic or atenolol does not adversely affect cognitive function in older adults.
Answers are grounded in this paper and cite their sources.
No cognitive harm from short-term thiazide or atenolol in older mild hypertensives; confirms safety and extends tolerability data.
No adverse effect upon cognitive function has been detected during the first 9 months of treatment by a thiazide diuretic (Moduretic; Merck Sharp & Dohme, Hoddesdon, UK) or a ß-blocking agent (atenolol) of moderately elevated blood pressure in a cohort of 2630 men and women aged between 65 and 74 years. Furthermore, no association was discovered between levels of systolic or diastolic blood pressure at outset and responses to standard tests of cognitive function. This study was carried out in general practices as part of the current Medical Research Council Treatment Trial of Mild Hypertension in the Elderly.
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Bird et al. (1990) studied this question.
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