This study provides the first evidence of the critical role of the Nav1.5 N-terminal region in channel function and the dominant-negative effect of trafficking-defective channels via α-subunit interaction.
This study reports for the first time the critical role of the Na(v)1.5 N-terminal region in channel function and the dominant-negative effect of trafficking-defective channels occurring through α-subunit interaction.
Clatot et al. (Wed,) studied this question.