Population
4 male patients with typical Brugada syndrome ST-segment elevation in V1-V3 or ventricular arrhythmias…
Comparison
Genetic screening for SCN5A mutations and in… vs Wild-type Na(v)1.5 channels and normal temperature
Design
Preclinical
Authors
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Alerts clinicians to temperature effects in SCN5A-related arrhythmias; leaves open translation to human fever-triggered Brugada syndrome.
Fever-exacerbated Brugada syndrome may result from temperature-dependent acceleration of sodium channel inactivation combined with loss-of-function mutations, rather than being mutation-specific.
Keller et al. (2005) studied this question.
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