April 1, 2003Journal of Cardiovascular Electrophysiology
A Newly Characterized SCN5A Mutation Underlying Brugada Syndrome Unmasked by Hyperthermia
Why the study?
Does hyperthermia unmask Brugada syndrome ECG patterns in patients with the SCN5A-H681P mutation?
Population
A single patient with Brugada syndrome unmasked by hyperthermia secondary to acute cholangitis, and in vitro…
Comparison
Hyperthermia and in vitro expression of… vs Normothermia and wild-type SCN5A.
Design
Case_report
Authors
Discussion
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Implication
Fever may unmask Brugada ECG in SCN5A-H681P carriers; case report extends variant data but leaves risk implications open.
Structured PICO
Does hyperthermia unmask Brugada syndrome ECG patterns in patients with the SCN5A-H681P mutation?
P
Population
A single patient with Brugada syndrome unmasked by hyperthermia secondary to acute cholangitis, and in vitro expression of the SCN5A-H681P mutation.
I
Intervention
Hyperthermia (clinical observation) and in vitro expression of SCN5A-H681P mutation.
C
Comparator
Normothermia (clinical observation) and wild-type SCN5A (implied for in vitro).
O
Outcome
ECG changes (ST segment elevation) and biophysical abnormalities of the sodium channel.surrogate
Fever can act as an environmental modifier to unmask Brugada syndrome in patients with the SCN5A-H681P mutation, which causes a significant loss of sodium window current.
Cite This Study
Mok et al. (2003) studied this question.