Why the study?
Does altering the oxidized to reduced NAD(H) balance regulate the cardiac sodium channel via mitochondrial ROS production?
Does altering the oxidized to reduced NAD(H) balance regulate the cardiac sodium channel via mitochondrial ROS production?
Altering the NAD(H) balance activates mitochondrial ROS production and reduces cardiac sodium current, providing a potential mechanistic link between altered metabolism, conduction block, and arrhythmic risk.
Altered NAD(H) balance may reduce cardiac sodium current via mitochondrial ROS; leaves open relevance to human conduction disease or arrhythmias.
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Liu et al. (2010) studied this question.
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