Does altering the oxidized to reduced NAD(H) balance regulate the cardiac sodium channel via mitochondrial ROS production?
Altering the NAD(H) balance activates mitochondrial ROS production and reduces cardiac sodium current, providing a potential mechanistic link between altered metabolism, conduction block, and arrhythmic risk.
Altering the oxidized to reduced NAD(H) balance can activate mitochondrial ROS production, leading to reduced I(Na). This signaling cascade may help explain the link between altered metabolism, conduction block, and arrhythmic risk.
Liu et al. (Fri,) studied this question.