Identifies a mechanistic link between cellular metabolism and cardiac sodium current regulation via pyridine nucleotides, providing insight into how GPD1-L mutations may downregulate Na(v)1.5.
Our results show that Na(v)1.5 is regulated by pyridine nucleotides, suggesting a link between metabolism and I(Na). This effect required protein kinase C activation and was mediated by oxidative stress. NAD+ could prevent this effect by activating PKA. Mutations of GPD1-L may downregulate Na(v)1.5 by altering the oxidized to reduced NAD(H) balance.
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Liu et al. (2009) studied this question.
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