Why the study?
Does preoperative CSF Aβ/tau ratio identify patients at higher risk for cognitive changes after surgery?
Does preoperative CSF Aβ/tau ratio identify patients at higher risk for cognitive changes after surgery?
Preoperative CSF Aβ/tau ratio may serve as a biomarker to identify patients at higher risk for cognitive decline following surgery.
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Does not yet support routine preoperative testing; hypothesis-generating for CSF biomarkers in postoperative cognition.
Preoperative CSF Aβ/tau ratio is associated with postoperative changes in specific cognitive domains. The presence of the Alzheimer's disease biomarker, specifically the Aβ/tau ratio, may identify patients at higher risk for cognitive changes after surgery.
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Xie et al. (2013) studied this question.
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