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The circulating cytokine response to pneumonia is heterogeneous and continues for more than a week after presentation, with considerable overlap between those who do and do not develop severe sepsis. Unbalanced activation is uncommon, and mortality is highest when both proinflammatory and anti-inflammatory cytokine levels are high.
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John A. Kellum (Mon,) studied this question.
synapsesocial.com/papers/69d8124e66a29169b4bee206 — DOI: https://doi.org/10.1001/archinte.167.15.1655
John A. Kellum
University of Pittsburgh Medical Center
Archives of Internal Medicine
University of Pittsburgh
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