What question did this study set out to answer?

To determine whether early life stress induced by fragmented maternal care reproduces human-like sex differences and developmental timing in depressive behaviors using a mouse model.

September 6, 2018NeuropsychopharmacologyOpen Access

Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model

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Authors

HGHaley L. GoodwillBrown University GMGabriela Manzano-NievesCornell University MGMeghan GalloNew York Psychoanalytic Society and Institute

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Implication

Preclinical study reveals female-specific depressive-like behaviors following early life stress in mice, highlighting mechanisms underlying sex-biased vulnerability to depression.

Key Points

To determine whether early life stress induced by fragmented maternal care reproduces human-like sex differences and developmental timing in depressive behaviors using a mouse model.
Exposed mouse pups to early life stress (ELS) from postnatal day 4 to 11 using a limited bedding model that induces fragmented maternal care.
Evaluated adolescent and young adult male and female mice using standard behavioral assays and an automated 5-to-10-day continuous home cage video recognition system.
Administered the fast-acting antidepressant ketamine to test for the reversibility of stress-induced home cage behavioral deficits.
ELS elicited robust depressive-like behaviors specifically in female mice, with deficits appearing during adolescence and worsening into adulthood, while males remained unaffected.
Continuous automated home cage tracking identified ongoing behavioral alterations in ELS females that phenocopy clinical features of human depression.
Treatment with ketamine rapidly rescued the depressive-like home cage behavioral alterations observed in adult ELS females.

Cite This Study

Goodwill et al. (2018) studied this question.

synapsesocial.com/papers/69d81ccf3eff0c9dfaae3727 https://doi.org/10.1038/s41386-018-0195-5

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Implication

Preclinical study reveals female-specific depressive-like behaviors following early life stress in mice, highlighting mechanisms underlying sex-biased vulnerability to depression.

Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model

Discussion

Member takes

Implication

Key Points

Cite This Study

Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model

Discussion

Member takes

Implication

Key Points

Cite This Study

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