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December 1, 2025Open Access

Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally

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Authors

JMJosephine C. McGowanJKJed KatzensteinNCNatalie S. Chace

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Overview

Randomized trial examines social behavior deficits and biomarker changes in mice, suggesting intergenerational consequences.

Key Points

  • This research aims to investigate how early life stress in mice affects social behavior and alters biomarkers during adolescence, with implications for intergenerational effects.
  • Utilized a limited bedding and nesting model to induce early life stress during postnatal days 3-9.
  • Assessed pup ultrasonic vocalizations, social behavior, thymus involution, and adrenal hypertrophy at adolescent age (P30).
  • Examined second-generation offspring to evaluate potential intergenerational effects.
  • Reduced ultrasonic vocalizations observed by P3, reflecting later deficits in social behavior.
  • Thymus weights were increased and adrenal glands were reduced in LBN adolescent mice, contrasting with adult stress responses.
  • Signs of precocious puberty noted in both sexes among second-generation LBN-exposed offspring.

Cite This Study

McGowan et al. (2025) studied this question.

synapsesocial.com/papers/6a20d4e98446b104fdecb203https://doi.org/10.1101/2025.11.27.690841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model2018 · 251 citations
  2. 2Sex-specific effects of early life stress exposure on memory performance and medial prefrontal cortex transcriptomic pattern of adolescent mice2024 · 1 citations
  3. 3Limited Bedding and Nesting as a Model for Early-Life Adversity in Mice2024 · 12 citations
  4. 4Consistent changes in global gene expression patterns despite strong variation in individual gene expression in the male mouse hippocampus following early life stress.2026
  5. 5Effect of Limited Bedding and Nesting in Early Ontogenesis on Gene Expression in the Hippocampus and Frontal Cortex of Adolescent Rats Subjected to Restraint2026