Defining the Intensity of Conditioning Regimens: Working Definitions
Authors
Discussion
Loading...
Member takes
Implication
Consensus report demonstrates standardized conditioning regimen categories in stem cell transplantation, highlighting cross-study comparability.
Key Points
- To establish uniform working definitions for categorizing the intensity of conditioning regimens utilized prior to hematopoietic stem cell transplantation.
- Stratified conditioning regimens into three distinct intensity classes based on duration of cytopenia and the requirement for stem cell support.
- Categorized commonly used clinical conditioning protocols according to specific agents, dosages, and combination regimens.
- Defined three consensus categories: myeloablative regimens that cause irreversible cytopenia requiring mandatory stem cell rescue, nonmyeloablative regimens causing minimal cytopenia manageable without rescue, and intermediate reduced-intensity conditioning.
- Assigned standard chemotherapy and radiation regimens to these three categories to enable consistent comparisons across clinical trials and transplant registries.
Cite This Study
Bacigalupo et al. (2009) studied this question.