May 22, 2023European Heart Journal61 citationsOpen Access
View Full PaperNT-proBNP and high intensity care for acute heart failure: the STRONG-HF trial
Structured PICO
Does high intensity care reduce 180-day HF readmission or death in patients with acute HF regardless of baseline NT-proBNP?
P
Population
Patients with acute heart failure enrolled in the STRONG-HF trial
I
Intervention
High intensity care (HIC) with guideline-directed medical therapy (GRMT) up-titration early post-discharge, utilizing increased NT-proBNP as guidance to increase diuretic therapy and reduce the GRMT up-titration rate
O
Outcome
180-day HF readmission or deathcomposite
High intensity care with rapid up-titration of guideline-directed medical therapy reduces 180-day HF readmission or death in acute heart failure patients irrespective of baseline NT-proBNP levels.
Abstract
Among patients with acute HF enrolled in STRONG-HF, HIC reduced 180-day HF readmission or death regardless of baseline NT-proBNP. GRMT up-titration early post-discharge, utilizing increased NT-proBNP as guidance to increase diuretic therapy and reduce the GRMT up-titration rate, resulted in the same 180-day outcomes regardless of early post-discharge NT-proBNP change.