Observational study reveals rapid antibody development and viral RNA clearance within weeks in infected blood donors, indicating minimal risk of transfusion transmission from seropositive blood.
IgM and IgG develop rapidly after viremia and before RNA levels become undetectable, which occurred a mean of 13.2 days after the index donation among donors in this study. WNV RNA detection by replicate TMA rarely persists for >40 days after the index donation and is accompanied by WNV-specific neutralizing antibody, consistent with an absence of WNV transmission via transfusion of seropositive blood components.
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Busch et al. (2008) studied this question.
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