Population
Brain tissue/cells expressing Kv4.3 channels
Comparison
Expression of Kvbeta1 or Kvbeta2 subunits vs Absence of auxiliary subunits
Design
Preclinical
Authors
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No immediate clinical implications for arrhythmia therapy; leaves open Kvbeta effects on human cardiac excitability.
Kvbeta subunits stimulate the expression of Kv4.3 channels by interacting with their C termini, increasing channel protein stability.
Yang et al. (2001) studied this question.
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