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February 1, 1996NeuronOpen Access

NAB Domain Is Essential for the Subunit Assembly of both α–α and α–β Complexes of Shaker-like Potassium Channels

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Key result

The NAB domain is essential for Kv beta 1-mediated inactivation and mediates the assembly of both alpha-alpha and alpha-beta complexes in Shaker-like potassium channels.

Population

Shaker-like K+ channels (Kv1 subfamily, RCK4, Shaker B, Shal2 of Kv4 subfamily)

Design

Preclinical

Authors

WYWeifeng YuSouth China Agricultural UniversityJXJia XuSichuan UniversityMLMan LiShihezi University

Discussion

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Member takes

Overview

No direct clinical implications for channelopathies; leaves open NAB as a research target for Kv channel modulation.

Structured PICO

P
Population
Shaker-like K+ channels (Kv1 subfamily, RCK4, Shaker B, Shal2 of Kv4 subfamily)
I
Intervention
Kv beta 1 binding and chimeric alpha subunits
O
Outcome
Inactivation of K+ channels and subunit assemblysurrogate

The NAB domain is essential for the assembly of both alpha-alpha and alpha-beta complexes in Shaker-like potassium channels, mediating their inactivation.

Cite This Study

Yu et al. (1996) studied this question. The NAB domain is essential for Kv beta 1-mediated inactivation and mediates the assembly of both alpha-alpha and alpha-beta complexes in Shaker-like potassium channels.

synapsesocial.com/papers/6aa2281274e5ec3ca1d3ca68https://doi.org/10.1016/s0896-6273(00)80062-8
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assembly of Voltage-gated Potassium Channels1995 · 167 citations
  2. 2A Novel β Subunit Increases Rate of Inactivation of Specific Voltage-gated Potassium Channel α Subunits1995 · 170 citations
  3. 3Molecular cloning and functional expression of a novel potassium channel β‐subunit from human atrium1995 · 128 citations
  4. 4Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation1990 · 1,553 citations
  5. 5Specification of Subunit Assembly by the Hydrophilic Amino-Terminal Domain of the Shaker Potassium Channel1992 · 460 citations