What question did this study set out to answer?

To assess how community population density and antibiotic consumption interact to affect the prevalence of antibiotic-resistant bacteria across different urban settings.

January 6, 2003Journal of Antimicrobial Chemotherapy

Influence of population density on antibiotic resistance

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NBNienke BruinsmaWorld Health Organization

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Implication

Comparative study reveals that geographic antibiotic density correlates strongly with resistant bacteria in healthy adults, indicating population crowding drives resistance.

Key Points

To assess how community population density and antibiotic consumption interact to affect the prevalence of antibiotic-resistant bacteria across different urban settings.
Quantified antibiotic consumption using defined daily dose per 1,000 inhabitants/day (DID) and per square kilometer (DSD) across three cities: St. John's (Canada), Athens (Greece), and Groningen (The Netherlands).
Isolated resistant Escherichia coli and enterococci from fecal samples collected from healthy community volunteers.
Calculated Pearson correlation coefficients (Pcc) between consumption metrics (DID versus DSD) and bacterial resistance rates.
Antibiotic consumption was over three-fold higher in Newfoundland (28 DID) and Greece (29 DID) than in The Netherlands (9 DID), yet Newfoundland had the lowest prevalence of resistant E. coli, reaching significance for cefazolin, oxytetracycline, and trimethoprim (P < 0.05).
Per-capita consumption (DID) correlated poorly with resistance prevalence (Pcc ranged from -0.93 to 0.87), whereas geographic consumption density (DSD) exhibited a strong correlation (Pcc ranged from 0.86 to 1.00).

Cite This Study

Nienke Bruinsma (2003) studied this question.

synapsesocial.com/papers/69d848698c03fbaff8beeac5 https://doi.org/10.1093/jac/dkg072

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Implication

Comparative study reveals that geographic antibiotic density correlates strongly with resistant bacteria in healthy adults, indicating population crowding drives resistance.

Influence of population density on antibiotic resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

Influence of population density on antibiotic resistance

Discussion

Member takes

Implication

Key Points

Cite This Study

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