Why the study?
Does a high serum creatinine concentration within the normal range indicate an increased risk of cerebrovascular disease in normotensive and hypertensive subjects?
Does a high serum creatinine concentration within the normal range indicate an increased risk of cerebrovascular disease in normotensive and hypertensive subjects?
Subtle impairment of renal function, indicated by high-normal serum creatinine, is a risk factor for stroke.
Answers are grounded in this paper and cite their sources.
High-normal creatinine may flag elevated cerebrovascular risk across BP strata; hypothesis-generating and should not yet change practice.
A high serum creatinine concentration within the normal range is a marker for increased risk of cerebrovascular disease in both normotensive and hypertensive subjects. These findings support the evidence indicating that subtle impairment of renal function is a factor for increased risk of stroke and suggest mechanisms in the pathogenesis of stroke that warrant further investigation.
No takes yet. Share an insight, caveat, or question.
Wannamethee et al. (1997) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: