Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart Failure

Figures

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  Figure 1. Flow chart depicting the sampling of initial YTCC cohort to produce final analytic sample. Abbreviations: FENa-DE, fractional excretion of sodium at peak diuresis per 2-fold higher diuretic dose; Na-DE; total sodium excreted per 2-fold higher diuretic dose; RAAS, renin-angiotensin-aldosterone system; YTCC, Yale Transitional Care Center.

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  Figure 2. Scatterplots of associations of plasma and urine total renin with Na-DE and FENa-DE. Scatterplots and lines of best fit for associations of (A) plasma total renin with Na-DE, (B) plasma total renin with FENa-DE, (C) urine total renin indexed to urine creatinine with Na-DE, and (D) urine total renin indexed to urine creatinine with FENa-DE. All outcomes and biomarkers are log2-transformed. Fitted lines from robust regression models use modified maximum likelihood estimation. Abbreviations: FENa-DE, fractional excretion of sodium at peak diuresis per 2-fold higher diuretic dose; Na-DE; total sodium excreted per 2-fold higher diuretic dose.