Plasma renin activity in patients with heart failure and reduced ejection fraction on optimal medical therapy
Key result
Plasma renin activity was 7.6 ng/ml/h in ambulatory chronic HFREF vs 1.5 ng/ml/h in acute decompensated HFREF, but only predicted cardiovascular mortality or readmission in acute HFREF (p=0.035).
Why the study?
Does plasma renin activity predict cardiovascular mortality or heart failure readmissions in patients with heart failure and reduced ejection fraction?
Population
226 participants including 76 healthy volunteers, 72 patients hospitalized for acute decompensated HFrEF…
Comparison
Measurement of Plasma Renin Activity (PRA) vs Comparison between ambulatory chronic HFrEF…
Design
Cohort
Authors
Discussion
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Member takes
Implication
PRA elevation signals higher event risk only in acute decompensated HFREF; leaves open whether renin-targeted interventions improve prognosis.
Study Design
Type
Observational (n=226)
Structured PICO
Does plasma renin activity predict cardiovascular mortality or heart failure readmissions in patients with heart failure and reduced ejection fraction?
P
Population
226 participants including healthy volunteers, patients hospitalized for acute decompensated HFREF, and ambulatory chronic HFREF patients without clinical signs of congestion.
E
Exposure
Measurement of Plasma Renin Activity (PRA)
C
Comparator
Comparison between ambulatory chronic HFrEF, acute decompensated HFrEF, and healthy volunteers
O
Outcome
Plasma renin activity (PRA) levels and their association with a composite of cardiovascular mortality or heart failure readmissionscomposite
Main Result
Absolute Event Rate: 7.6% vs 1.5%
p-value: p=< 0.05
Plasma renin activity is elevated in ambulatory chronic HFrEF but only predicts cardiovascular mortality or heart failure readmissions in patients with acute decompensated HFrEF.
Cite This Study
Nijst et al. (2017) conducted an observational in Heart failure with reduced ejection fraction (HFREF) (n=226). Plasma renin activity vs. Healthy volunteers and acute decompensated HFREF patients was evaluated on Plasma renin activity (PRA) (p=< 0.05). Plasma renin activity was 7.6 ng/ml/h in ambulatory chronic HFREF vs 1.5 ng/ml/h in acute decompensated HFREF, but only predicted cardiovascular mortality or readmission in acute HFREF (p=0.035).