Key result
Low plasma renin activity in hypertensive patients was associated with higher left ventricular hypertrophy (50% vs 43.3%) but lower advanced retinopathy (10% vs 27.3%) than normal or high PRA.
Why the study?
Is plasma renin activity associated with left ventricular hypertrophy and retinopathy in patients with arterial hypertension?
Population
72 patients with arterial hypertension, including 51 with essential hypertension and a subset with renal…
Design
Cross-sectional
Authors
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Differential PRA associations with hypertensive target organ damage are hypothesis-generating; should not change practice pending prospective data.
Cross-Sectional (n=72)
Is plasma renin activity associated with left ventricular hypertrophy and retinopathy in patients with arterial hypertension?
Absolute Event Rate: 50% vs 43.3%
Blood pressure levels are the primary driver of left ventricular hypertrophy in hypertension, while the renin-angiotensin system may play a direct role in the development of hypertensive retinopathy.
Stødkilde‐Jørgensen et al. (1974) conducted a cross-sectional in Arterial hypertension (n=72). Low plasma renin activity (PRA) vs. Normal or high PRA was evaluated on Left ventricular hypertrophy (LVH). Low plasma renin activity in hypertensive patients was associated with higher left ventricular hypertrophy (50% vs 43.3%) but lower advanced retinopathy (10% vs 27.3%) than normal or high PRA.
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