Relation of the renin-angiotensin-aldosterone system to clinical state in congestive heart failure.
Population
23 patients with severe congestive heart failure divided into three groups: recent onset severe pump failure…
Design
Cohort
Authors
Discussion
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Implication
Transient RAAS activation in decompensated HF warrants caution against indefinite intensification; leaves open optimal timing of inhibition in severe dysfunction.
Structured PICO
P
Population
23 patients with severe congestive heart failure (NYHA class III-IV) divided into three groups: recent onset severe pump failure with pulmonary edema (n=5), recent cardiac decompensation superimposed on chronic CHF (n=9), and chronic stable CHF (n=9). An additional 9 patients with acute, apparently uncomplicated myocardial infarction were also studied.
O
Outcome
Plasma renin activity (PRA) and plasma aldosterone levels across different clinical states of heart failuresurrogate
The renin-angiotensin-aldosterone system is activated during acute decompensation of heart failure, likely driven by decreased systemic blood pressure and cardiac output, but normalizes upon clinical stabilization.
Cite This Study
Dzau et al. (1981) studied this question.