Key result
Plasma norepinephrine levels increased significantly in proportion to the severity of chronic congestive heart failure and correlated positively with systemic vascular resistance.
Population
117 normotensive patients with chronic congestive heart failure, including a subset of 6 patients with…
Design
Cohort
Authors
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Norepinephrine elevation may mark sympathetic drive in worsening CHF; hypothesis-generating for neurohormonal targeting, pending randomized trials.
Observational (n=117)
Absolute Event Rate: 0.51% vs 0.15%
p-value: p=<0.001
The sympathetic nervous system and renin-angiotensin system contribute to the elevation of systemic vascular resistance and pulmonary wedge pressure in chronic congestive heart failure.
Nishioka et al. (1982) conducted an observational in Chronic congestive heart failure (n=117). Severity of congestive heart failure vs. Mild or no heart failure (NYHA Class I-II) was evaluated on Plasma norepinephrine (P-NE) concentration (p=<0.001). Plasma norepinephrine levels increased significantly in proportion to the severity of chronic congestive heart failure and correlated positively with systemic vascular resistance.
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