Concurrent neutral endopeptidase and ACE inhibition in experimental heart failure: Renal and hormonal effects
Why the study?
Does SCH 34826 alone or combined with captopril improve renal and hormonal parameters in a rat model of experimental heart failure?
Population
Rat model of experimental congestive heart failure (coronary-ligation) and sham-operated control rats
Comparison
SCH 34826 90 mg/kg sc or orally 90 mg/kg b.i.d… vs Vehicle or captopril alone
Design
Preclinical
Follow-up
36 hours
Authors
Discussion
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Implication
No added renal benefit from NEP inhibition with ACEI in rat CHF; leaves open human translation of dual blockade.
Structured PICO
Does SCH 34826 alone or combined with captopril improve renal and hormonal parameters in a rat model of experimental heart failure?
P
Population
Rat model of experimental congestive heart failure (coronary-ligation) and sham-operated control rats
I
Intervention
SCH 34826 (NEP inhibitor) 90 mg/kg sc or orally 90 mg/kg b.i.d. for 36 h, alone or combined with captopril (0.2 mg/ml in drinking water)
C
Comparator
Vehicle or captopril alone
O
Outcome
Renal and hormonal effects including plasma ANP, plasma renin activity, natriuresis, kaliuresis, cGMP excretion, and aldosterone excretionsurrogate
In a rat model of experimental heart failure, NEP inhibition elevated plasma ANP but lacked major beneficial renal or hormonal effects when combined with ACE inhibition.
Cite This Study
Kristian Helin (1993) studied this question.