December 14, 1999Circulation
Renal Response to Acute Neutral Endopeptidase Inhibition in Mild and Severe Experimental Heart Failure
Why the study?
Does acute NEP inhibition with candoxatrilat improve renal hemodynamics and sodium excretion in experimental mild and severe heart failure?
Population
24 anesthetized dogs divided into 4 groups: normal, mild CHF, severe CHF, and severe CHF with chronic AT1…
Comparison
Acute neutral endopeptidase inhibitor… vs Responses compared across the 4 groups
Design
Preclinical
Follow-up
Acute
Authors
Discussion
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Implication
NEP inhibition may enhance renal function in mild experimental CHF but not severe; hypothesis-generating for clinical translation.
Structured PICO
Does acute NEP inhibition with candoxatrilat improve renal hemodynamics and sodium excretion in experimental mild and severe heart failure?
P
Population
24 anesthetized dogs divided into 4 groups: normal (n=8), mild CHF (n=6, produced by rapid ventricular pacing at 180 bpm for 10 days), severe CHF (n=5, produced by pacing at 245 bpm for 10 days), and severe CHF with chronic AT1 receptor antagonism (n=5).
I
Intervention
Acute neutral endopeptidase (NEP) inhibitor candoxatrilat (8 microg. kg(-1). min(-1))
C
Comparator
Responses compared across the 4 groups (normal, mild CHF, severe CHF, severe CHF with AT1 receptor antagonism)
O
Outcome
Renal hemodynamics and sodium excretion (urinary sodium excretion and glomerular filtration rate)surrogate
Acute NEP inhibition enhances renal function and sodium excretion in mild experimental heart failure, but these effects are attenuated in severe heart failure.
Cite This Study
Chen et al. (1999) studied this question.