April 1, 1995Circulation
The Role of Neutral Endopeptidase in Dogs With Evolving Congestive Heart Failure
Key result
Chronic neutral endopeptidase inhibition with candoxatril increased sodium excretion and renal cGMP generation in dogs with evolving congestive heart failure compared to untreated controls.
Why the study?
Does neutral endopeptidase inhibition with candoxatril improve renal responses to ANF and sodium excretion in dogs with evolving congestive heart failure?
Population
13 conscious dogs with evolving congestive heart failure produced by rapid ventricular pacing at 250 beats…
Comparison
Candoxatril 10 mg/kg PO BID throughout evolving… vs Untreated controls
Design
Preclinical
Follow-up
6 days
Authors
Discussion
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Implication
Hypothesis-generating for NEP inhibition in evolving HF; leaves open translation to human renal sodium handling.
Structured PICO
Does neutral endopeptidase inhibition with candoxatril improve renal responses to ANF and sodium excretion in dogs with evolving congestive heart failure?
P
Population
13 conscious dogs with evolving congestive heart failure produced by rapid ventricular pacing, followed for 6 days.
I
Intervention
Candoxatril (neutral endopeptidase inhibitor) 10 mg/kg PO BID throughout evolving CHF, with responses to exogenous atrial natriuretic factor (ANF) 10 micrograms/kg IV bolus assessed at baseline and after 6 days
C
Comparator
Untreated controls
O
Outcome
Sodium excretion and renal cGMP generation in response to endogenous and exogenous ANFsurrogate
Neutral endopeptidase inhibition with candoxatril enhances renal responsiveness to ANF and improves sodium balance in a canine model of evolving heart failure.
Cite This Study
Margulies et al. (1995) studied Evolving congestive heart failure (n=13). Neutral endopeptidase inhibition (NEP-I) with candoxatril vs. Untreated controls was evaluated on Sodium excretion and renal cGMP generation in response to exogenous ANF. Chronic neutral endopeptidase inhibition with candoxatril increased sodium excretion and renal cGMP generation in dogs with evolving congestive heart failure compared to untreated controls.