Pulmonary and urinary clearance of atrial natriuretic factor in acute congestive heart failure in dogs.
View Full Paper
Ask AI
Bookmark
Share
Why the study?
Does neutral endopeptidase inhibition alter the pulmonary and urinary clearance of atrial natriuretic factor in dogs with acute congestive heart failure?
Population
Dogs with acute experimental congestive heart failure
Comparison
Neutral endopeptidase inhibition (NEPI) vs Baseline (before CHF) and acute CHF without NEPI
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
NEP inhibition may preserve ANF clearance in acute CHF models; hypothesis-generating for human translation.
Structured PICO
Does neutral endopeptidase inhibition alter the pulmonary and urinary clearance of atrial natriuretic factor in dogs with acute congestive heart failure?
P
Population
Dogs with acute experimental congestive heart failure
I
Intervention
Neutral endopeptidase inhibition (NEPI)
C
Comparator
Baseline (before CHF) and acute CHF without NEPI
O
Outcome
Pulmonary and urinary clearance of atrial natriuretic factor (ANF)surrogate
This study demonstrates that neutral endopeptidase plays an important role in the pulmonary and urinary metabolism of endogenous ANF during acute congestive heart failure in dogs.
Cite This Study
Perrella et al. (1991) studied this question.
Topics
View Full Paper
Ask AI
Bookmark
Share