Clearance receptor-mediated control of atrial natriuretic factor in experimental congestive heart failure
Key result
Chronic heart failure does not alter total metabolic clearance rate of ANF in preclinical models.
- P NS
- n=13
Why the study?
The regulation of circulating atrial natriuretic factor by clearance receptors and their role in chronic congestive heart failure is not fully understood.
Does infusion of C-ANF-(4-23) alter ANF clearance rates and urinary sodium excretion in dogs with experimental congestive heart failure?
Comparison
Infusion of C-ANF-(4-23) vs control group without CHF
Design
Experimental study in mongrel dogs
Authors
Discussion
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Implication
Preserved ANF clearance in canine CHF model; hypothesis-generating for receptor pathway, requires human validation.
Structured PICO
Does infusion of C-ANF-(4-23) alter ANF clearance rates and urinary sodium excretion in dogs with experimental congestive heart failure?
P
Population
13 mongrel dogs (7 with chronic congestive heart failure and 6 controls) studied to determine clearance rates of atrial natriuretic factor.
E
Exposure
Infusion of C-ANF-(4-23), a ring-deleted analogue of ANF
C
Comparator
Control group of dogs without congestive heart failure
O
Outcome
Total metabolic (TMCR), pulmonary (PCR), and renal clearance rates (RCR) of ANFsurrogate
Main Result
Absolute Event Rate: 1534% vs 1735%
p-value: p=NS
In experimental CHF, the total functional activity of the ANF clearance receptor pathway is preserved and does not contribute to elevated endogenous ANF or renal ANF resistance.
Cite This Study
Brandt et al. (1994) studied Chronic congestive heart failure (n=13). Chronic congestive heart failure vs. Control group was evaluated on Total metabolic clearance rate (TMCR) of ANF (p=NS). In an experimental model, total metabolic clearance rate of ANF was not significantly altered in dogs with chronic congestive heart failure compared to controls (1,534 vs 1,735 ml/min; P=NS).