Why the study?
Does atrial natriuretic factor (ANF) infusion alter diuresis, natriuresis, and cGMP production in rabbits with congestive heart failure compared to controls?
Population
Rabbits with congestive heart failure induced by traumatic aortic regurgitation and abdominal aortic stenosis
Comparison
Atrial natriuretic factor (ANF) infusion vs Control rabbits
Design
Preclinical
Authors
Loading...
May indicate post-receptor defect in ANF resistance; leaves open intracellular targets for future animal and human studies.
Does atrial natriuretic factor (ANF) infusion alter diuresis, natriuresis, and cGMP production in rabbits with congestive heart failure compared to controls?
The blunted renal response to ANF in congestive heart failure is likely due to an intracellular defect beyond the second messenger, as glomerular ANF receptor density and cGMP production remain preserved.
Isnard et al. (1993) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: