Mechanisms involved in the response to prolonged infusion of atrial natriuretic factor in patients with chronic heart failure.
Why the study?
Does prolonged infusion of atrial natriuretic factor improve cardiovascular and renal hemodynamics in patients with chronic heart failure?
Population
Patients with chronic heart failure
Comparison
Prolonged infusion of atrial natriuretic factor… vs Baseline values prior to infusion
Design
Cohort
Follow-up
20 hours
Authors
Discussion
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Member takes
Implication
May limit sustained ANF use in chronic HF; leaves open whether alternative regimens overcome tolerance.
Structured PICO
Does prolonged infusion of atrial natriuretic factor improve cardiovascular and renal hemodynamics in patients with chronic heart failure?
P
Population
Patients with chronic heart failure
I
Intervention
Prolonged infusion of atrial natriuretic factor (ANF) titrated to produce a 30% decrease in pulmonary capillary wedge pressure or a 20% increase in cardiac output (average dose 75 +/- 4 ng/kg/min), administered for 20 hours
C
Comparator
Baseline values prior to infusion
O
Outcome
Cardiovascular and renal response (including central filling pressures, cardiac output, diuresis, glomerular filtration rates, plasma aldosterone, and plasma cyclic GMP levels)surrogate
Prolonged ANF infusion in heart failure patients produces only transient hemodynamic benefits and causes extravascular fluid shifts, which may limit its long-term therapeutic potential.
Cite This Study
Münzel et al. (1991) studied this question.