August 1, 1987Journal of Hypertension
Effects of Atrial Natriuretic Factor on Natriuresis and cGMP in Patients with Essential Hypertension
Key result
Infusion of human atrial natriuretic factor resulted in significantly higher mean plasma cGMP concentrations in hypertensive patients compared to normotensive controls (30.7 vs 15.6 pmol/ml, P<0.05).
Why the study?
Does h-ANF infusion affect natriuresis and cGMP levels differently in patients with mild essential hypertension compared to normotensive controls?
Population
12 subjects (5 patients with mild essential hypertension and 7 normotensive controls)
Comparison
Human atrial natriuretic factor infused at rates… vs Normotensive controls receiving the same infusion
Design
Other
Follow-up
90 minutes
Authors
Discussion
Loading...
Member takes
Implication
Enhanced cGMP response to ANF in mild hypertension should not change practice; leaves open altered signaling as a research target.
Structured PICO
Does h-ANF infusion affect natriuresis and cGMP levels differently in patients with mild essential hypertension compared to normotensive controls?
P
Population
12 subjects (5 patients with mild essential hypertension and 7 normotensive controls)
I
Intervention
Human atrial natriuretic factor (h-ANF) infused at rates of 0.8, 1.6 and 3.2 micrograms/min over three successive 30-min periods
C
Comparator
Normotensive controls receiving the same infusion (and vehicle only)
O
Outcome
Plasma cGMP concentration, diuresis, natriuresis, and cGMP excretionsurrogate
Main Result
Absolute Event Rate: 30.7% vs 15.6%
p-value: p=<0.05
Patients with mild essential hypertension exhibit enhanced plasma cGMP responses to h-ANF infusion compared to normotensive controls, despite normal natriuretic and diuretic responses.
Cite This Study
Cusson et al. (1987) studied Essential hypertension (n=12). Human atrial natriuretic factor (h-ANF) vs. Normotensive controls was evaluated on Mean plasma cGMP concentration after 90 min infusion (p=<0.05). Infusion of human atrial natriuretic factor resulted in significantly higher mean plasma cGMP concentrations in hypertensive patients compared to normotensive controls (30.7 vs 15.6 pmol/ml, P<0.05).